Ethical and Social Challenges of Genomic and Precision Medicine
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Course Date: 15 September 2014 to 03 November 2014 (7 weeks)
Knowledge linking genomics to health and disease is rapidly expanding. Translation of this knowledge into clinical and public health practice offers promising opportunities but also raises a host of ethical, legal, social, and policy questions. Using case examples, this inter-disciplinary course will explore the challenges of genomic and precision medicine.
Wylie Burke MD PhD is Professor and former
Chair of the Department of Bioethics and Humanities at the University of
Washington, Adjunct Professor of Medicine, and Member of the Fred Hutchinson
Cancer Research Center. Her work focuses
on the ethical and policy implications of genetic information in research and
health care. She directs the University of Washington Center for Genomics and
Healthcare Equality, an NHGRI Center of Excellence in Ethical, Legal, and
Social Implications (ELSI) Research; and co-directs the Northwest-Alaska
Pharmacogenomics Research Network, a research partnership involving
universities and tribal communities in Alaska, Montana and Washington. Dr.
Burke received a PhD in Genetics and an MD from the University of Washington. She trained in Internal Medicine at the
University of Washington, where she was also a Medical Genetics Fellow. She is
a member of the Institute of Medicine and past President of the American
Society of Human Genetics, and was the 2013-2014 Presidential Chair at the
University of California San Francisco.
Dr. Barbara A. Koenig is a Professor of Medical Anthropology & Bioethics and Co-Director of the Center of Excellence in Translational Genomics & Ethics at the University of California, San Francisco. For more information on the Center of Excellence, visit http://www.ct2g.org/
Julie N Harris-Wai, Ph.D., M.P.H. is a social and
behavioral scientist at Kaiser Permanente’s (KP) Division of Research and an
Assistant Adjunct Professor in the Department of Social and Behavioral Sciences
at the University of California, San Francisco. Dr. Harris-Wai has a diverse
background in community health promotion, bioethics, and social and behavioral
sciences. She received her Ph.D. in public health genomics at the University of
Washington, followed by a fellowship in population health sciences with the
Robert Wood Johnson Foundation’s Health and Society Scholars Program at UC
Berkeley and UC San Francisco. Dr. Harris-Wai’s research focuses on examining
the social and ethical factors influencing how (and why) genomic technologies
are translated from the research setting into clinical care, and the impact
these technologies have on health disparities and underserved communities. The
ultimate goal of Dr. Harris-Wai’s work is to identify policies and programs
that improve the appropriate use of genomic technologies for all communities.
In addition to being an accomplished researcher, Dr.
Harris-Wai is also a dedicated educator and has taught courses in research
ethics, community-based-participatory research, qualitative research methods,
and Public Health Genomics. She combines her interests in education and
research in her role as the associate director of the UCSF/KP Center of
Excellence in research on Translational Genomics and Ethics. In this position,
she collaborates with a multi-disciplinary team of investigators at UCSF and
Kaiser Permanente to develop a training program focused on the bioethical,
legal, and ethical implications of translational genomics (www.ct2g.org).
This six week, inter-disciplinary course provides an
introduction to ethical, legal, social, and policy issues that arise in the
translation of genomic knowledge into medical and public health practice. It
considers challenges in health related and reproductive testing/screening
focusing on six specific areas:
Pre-conception genetic diagnosis, and prenatal
Use of genomic sequencing technologies to diagnose
and predict disease
Targeting genomic testing/screening by
Direct-to-consumer genomic testing/screening
Use of “big data” for genomic research and genomic
The course uses case studies to illustrate key
themes in genomic translation. Students will have an opportunity to interrogate
and critique a promising science through lectures and readings from a range of
disciplinary perspectives (e.g. history, sociology, genetics, medicine,
bioethics) and online discussion.
Will I get a Statement of Accomplishment after completing this class?
Yes. Students who successfully complete the class will have the opportunity to receive a Statement of Accomplishment signed by the instructor.
Is this class eligible for Signature Track?
Yes. Prior to the beginning of the class, and during the first two weeks, students may sign up for Signature Track to earn a Verified Certificate. Details on Signature Track are available from Coursera in their Signature Track Guidebook.
Will Continuing Education credit for practicing physicians be available for this class?
After the class begins, please check the course site for detailed information about earning Continuing Medical Education (CME) credits for successfully completing this course.
Week 1: Introduction Week 2: Reproductive Genetics Week 3: Screening Week 4: Genetic Technology in the Prediction and Diagnosis of Disease Week 5: Race and Genetics Week 6: Direct-to-Consumer Testing Week 7: Where Do We Go From Here?
course includes weekly lectures that will range from one to to hours in length. To coincide with the lectures each week, there will also be two to three hours of readings